People who inject drugs (PWID) refers to individuals who introduce psychoactive substances into their bodies via injection, a behavior carrying significant health risks. This makes PWID a “key population” for public health interventions, particularly regarding HIV, viral hepatitis, and overdose prevention. Beyond the act of injection, PWID often experiences a complex interplay of vulnerabilities, including increased risk of infectious diseases, overdose, mental health challenges, social marginalization, healthcare inequities, human rights violations, and exclusion from policy discourse. 

The sustainability of programs supporting PWIDs is threatened by funding challenges, such as the current withdrawal of PEPFAR support. Addressing this and other systemic issues requires a rights-based approach that prioritizes inclusivity, equity, and long-term solutions for this vulnerable group.

The World Health Organization (WHO) advocates for comprehensive harm reduction strategies for PWID, including needle and syringe programs (NSPs), opioid substitution therapy (OST), access to naloxone, and integrated healthcare services. This approach aims to minimize the negative health and social consequences associated with drug injection and promote the well-being of PWID, recognizing their right to health and dignity.